Until I have time to do my own research, Scott Forsgren, aka Better Health Guy, has done it for me:
HLA genes code various proteins on the outer portion of cells. The immune system uses HLA to determine the difference between “self” and “non-self”. HLA is involved in the steps responsible for antibody formation. These genes have been associated with an inability of the body to recover from illnesses resulting from Lyme disease, molds, and other sources. In the event that a person has a susceptible genotype, the body does not recognize the toxins as a foreign invader and this, they are allowed to remain in the body. This causes long-term and perpetual ill-health. It has been asserted that nearly 100% of people that become ill after exposure to a biotoxin can be shown to have a predisposition to that biotoxin through the HLA-DR genotype. Many of us have bodies that simply do not recognize the presence of these toxic substances and thus do nothing to eliminate them. Dr. Shoemaker uses the terms “Lyme susceptible” or “mold susceptible” or “multi-susceptible” to categorize one’s HLA genotype.
HLA testing is done through LabCorp and can provide some interesting explanations for why we often remain ill. In my case, I presented with a 4-3-53 genotype which is multi-susceptible and is also termed the “dreaded genotype” by some. It means that your body is not capable of dealing with toxins from many origins including Lyme disease and mold exposure. It is not my belief that the genetic results imply that you cannot or will not recover. However, I do think that they provide another piece of information to help us understand and adapt treatment protocols to provide us with the best possible chances of recovering.
I had purchased the book Mold Warriors and had it sitting on my shelf for many months. Then, in the course of about one week, several people through my web site mentioned the book. I decided that there must be a reason that I was now supposed to read it. I found the book to be an entirely different perspective on Lyme disease and mold-illness than what I had ever really understood in the past. It was not my position that my previous understanding or treatment approach was incorrect, but that maybe I could understand more of the puzzle by looking at things in this new way. I may then be able to integrate some of these new theories into my treatment regimen and, as a result, take my health to the next level.
In Lyme disease and certainly mold illnesses, the biotoxins themselves are a major component of the resulting symptom picture. Most Lyme-literate doctors will agree that the toxins which are produced from Lyme disease are likely the reason that most people continue to feel quite ill. In genetically susceptible individuals, these toxins are excreted by the gallbladder and then almost entirely reabsorbed by the remainder of the digestive system. They continue to circulate in the body with no mechanism for removal and can continue to recirculate for years.
The symptoms of mold illnesses include:
Dr. Shoemaker contends that people with mold-related biotoxin illness are not necessarily infected with a mold or fungus, but that they are exposed to the spores that these produce which are highly toxic. When biotoxin illness is confirmed, Dr. Shoemaker often uses a combination treatment of Cholestyramine (CSM) and Actos, along with a low amylose diet. CSM works by removing the toxins that have entered the body. Though it should still be a key goal to avoid the toxin-producing substances in the first place, CSM can help to bind to the toxins already in the body and shuttle them out of the system. A low amylose diet is an extremely important part of the treatment protocol, as it helps to minimize (along with the Actos) the pro-inflammatory cytokines, which are often elevated in individuals with biotoxin induced illnesses. Further information on the role of CSM, Actos and a low Amylose diet, go here.
Quite interestingly, the genes for celiac disease/gluten intolerance have a significant overlap with the mold genotypes (e.g., DQ2 accounts for 90% of individuals diagnosed with traditional celiac disease). Thus, many individuals with a mold illness may be initially diagnosed only as having gluten intolerance, yet they never fully recover on a gluten-free diet alone. Coincidentally, the low amylose diet recommended as part of the treatment protocol is naturally a gluten-free diet. For further information on celiac disease/gluten intolerance and available testing, go here.
Next comes Dr. Shoemaker’s “Biotoxin Pathway”. This helps to explain all of the downstream effects of these toxins in someone that is genetically susceptible to biotoxin illness. It is quite complicated and warrants significant additional study. I highly recommend you read the book and understand the details behind it. Once you pick it up, I suspect you won’t be able to put it down.
The “Biotoxin Pathway” shows the cascade of events that starts a biotoxin illness in those who are HLA-susceptible the moment that they are exposed to a biotoxin. It leads to increased leptin, increased cytokines, increased MMP-9 (MMP-9 is a global measure of cytokine activity in the body), reduced VEGF, and reduced MSH (alpha-melanocyte stimulating hormone). Reduced MSH leads to reduced ADH (antidiuretic hormone), reduced sex hormones, changes in cortisol and ACTH (adrenocorticotropic hormone), prolonged illness, resistant staphylococci infections, gastrointestinal problems, chronic pain, and sleep disturbances. All of these are downstream effects of a biotoxin in an HLA-susceptible individual. It is mind-boggling to try and comprehend the magnitude of negative impacts on so many body systems caused by a biotoxin.
You can find a Lab Order Sheet and a Draw Sheet with expected ranges online. For more information on this area, visit Dr. Shoemaker’s web sites at http://www.SurvivingMold.com and http://www.chronicneurotoxins.com.
I’ve written three articles in the Public Health Alert related to Dr. Shoemaker’s work. They can be found here:
Biotoxin Pathway Holds Key Pieces of Puzzle
VCS Testing: What Mine Eyes May Tell
While it does not contain all of the most recent advances in biotoxin illness, Dr. Shoemaker participated in a radio interview a few years ago which can be found here. A radio show on OneRadioNetwork.comwith Dr. Shoemaker can be found here.
UPDATES: In December 2010, Dr. Shoemaker released his latest book. It is one that I have been waiting to read for quite some time. Not only did he release his new book, but he created a very informative new web site. Several things have changed in both testing and treatment from the earlierMold Warriors book which was published in 2005.
In October 2011, I attended a two day lecture with Dr. Shoemaker which included all the latest information on topics such as TGFb1, C4a, ERMI, and much more. My summary of this event can be found here.
RECOMMENDATION: I personally recommend that anyone with chronic Lyme disease or other chronic illnesses have their HLA type tested and do the ERMI from Mycometrics. The ERMI continues to shed light on complex situations. If someone lives in a moldy environment, it is unlikely that they will ever get well. Unfortunately, this seems a topic that most are unwilling to consider and thus their illnesses continue. Note that some relatively new ERMI interpretation criteria have been made available here.