MTHFR Mutation- C677T

I keep wondering about Jackson’s two copies of C677T.  There is a whole website dedicated to MTHFR…  If you want the whole 32 page article, copy and paste the link below into your browser.  I embedded the first chunk of it here.  I printed it out to show our LLMD since one of Jackson’s supplements is Folic Acid, and it says below, “folic acid needs to be avoided more seriously by homozygous individuals.”

MTHFR C677T Mutation: Basic Protocol

by  on February 24, 2012 in C677T MTHFR Mutations

Have one or two copies of the MTHFR C677T mutation?

Don’t know what to do?

After working with 100′s of individuals with this defect, I’ve developed a protocol which may help a significant number of people.

I want to make it absolutely clear that while the MTHFR C677T mutation may be common across a number of individuals, the outcome of supplementing with various nutrients can vary tremendously due to other genetic defects, dietary and lifestyle choices and environmental exposures.

Some of these recommendations require a full explanation. Due to the nature of this article, it is not possible to do so. If the recommendation is listed, it is critically important.

Let it be known that the information presented below is for your information only and is not intended to treat, diagnose or prescribe in any way. Use the information at your own risk. Always seek the advice from your physician.

Part I pertains to supporting both heterozygous (1 copy of C677T) and homozygous (2 copies of C677T) MTHFR mutations. Part II pertains to mainly homozygous individuals but may also be tried by heterozygous individuals if desired.


The biggest differences in recommendations between these two types of mutations are:

  1. folic acid needs to be avoided more seriously by homozygous individuals
  2. the amount of methylfolate required for homozygous mutations is greater
  3. the blood thinning requirement is greater for homozygous individuals

Here are the common recommendations for supporting those with C677T MTHFR mutations:

  1. Limit ingestion of folic acid in fortified foods as you cannot process folic acid well.
  2. Limit or cease taking supplements or drugs with folic acid in them. Talk with your doctor before stopping.
  3. Avoid folic acid blocking drugs such as birth control or Methotrexate.
  4. Avoid drugs which increase homocysteine such as Nitrous Oxide (most used in dentistry)
  5. Avoid antacids as they block absorption of vitamin B12 and other nutrients
  6. Begin understanding which of your symptoms may be related to the C677T MTHFR mutation.
  7. Measure homocysteine levels – properly!
  8. Inform your family members so they can also test for the MTHFR mutation
  9. Find a doctor who is knowledgeable about MTHFR or is willing to learn
  10. If you are pregnant, find an OB/GYN or midwife who is knowledgeable about MTHFR.
  11. Eliminate Gluten from your diet – especially wheat.
  12. Eliminate or reduce Dairy from your diet. If you must have dairy, use Goat milk.
  13. Sauna or sweat somehow (epsom salt baths, sports, yoga..) at least once to three times a week.
  14. Limit intake of processed foods
  15. Increase intake of whole foods and home-prepared meals
  16. Eat the Rainbow of colors from fruits and vegetables – daily
  17. Castor Oil Packs over your abdomen daily during times of pain, soreness, cramps
  18. Vegetable/Fruit Juice Diet with Chia Seeds during times of pain, soreness, cramps
  19. Limit intake of high methionine-containing foods if homocysteine elevated
  20. Coffee Enemas during times of detoxification or pain
  21. Filter chlorine from your drinking watershower and bath.
  22. Drink at least two liters of filtered water daily mixed with vitamin C and electrolytes.
  23. Eat smaller, but more frequent meals, throughout the day with some form of protein.
  24. Limit protein intake to approximately 0.7 grams protein per kilogram of body weight.
  25. Remove mercury amalgams and root canals with a trained biological dentist.
  26. Avoid cooking, drinking, storing and heating in any type of plastic container.
  27. Use an air purifier in your home and office
  28. Eliminate carpets from your home and install low VOC wood or tile flooring.
  29. Eat grass-fed beef, free range, hormone free and antibiotic meats and eggs
  30. Cook with electric stove and oven and remove gas stove and oven.

General Nutrient Recommendations for C677T MTHFR mutations:

  • Methylfolate
  • Methylcobalamin
  • Betaine in the form of TMG
  • NAC
  • Glutathione
  • Pyridoxal-5-phosphate
  • Riboflavin
  • Curcumin
  • Mixed tocopherals (vitamin E)
  • Silymarin (Milk Thistle)
  • Phosphatidylcholine
  • Nattokinase
  • Vitamin C
  • Vitamin D3
  • Comprehensive multivitamin/multimineral
  • Probiotics

Typical Pharmaceuticals Recommended for the C677T MTHFR Mutation
There are many pharmaceuticals commonly recommended for C677T MTHFR mutations yet they are ill-advised as they contain inferior forms of vitamin B12, little or no vitamin B6 or the incorrect form of folic acid.

It should also be known that all pharmaceutical drugs below contain food coloring, dyes, anti-caking agents or other compounds that should be avoided.

  • Deplin 7.5 mg or 15 mg (don’t recommend this often at all – very rarely)
  • Cerefolin NAC
  • Metanx
  • Lovenox
  • Baby aspirin

Compare the drugs used for MTHFR mutations here


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